Isle of Dogs ( 犬ヶ島 , Inugashima ) is a 2018 stop-motion animated film written, produced and directed by Wes Anderson . Set in a dystopian near-future Japan, the film follows a group of dogs who helps a young boy searching for his dog after the whole species is banished to an island after a canine-flu outbreak. The ensemble voice cast includes Bryan Cranston , Edward Norton , Bill Murray , Jeff Goldblum , Bob Balaban , Greta Gerwig , Frances McDormand , Courtney B. Vance , Fisher Stevens , Harvey Keitel , Liev Schreiber , Scarlett Johansson , Tilda Swinton , F. Murray Abraham , Frank Wood , Kunichi Nomura and Yoko Ono .